Life Sciences
Industrial Hygiene Analytical Laboratory
AIHA-Accredited Analytical Laboratory for Method Development and Sample Analysis
Trinity Consultants’ SafeBridge team operates an industrial hygiene analytical laboratory that has been accredited by the American Industrial Hygiene Association (AIHA) for the analysis of active pharmaceutical ingredients (APIs). The laboratory employs the most sensitive techniques in the industry to detect potent drugs at very low concentrations in the workplace.
SafeBridge’s AIHA-accredited analytical laboratory employs the most sensitive techniques in the industry to detect potent drugs at very low concentrations in the workplace. These include potent drugs such as steroids, peptide hormones, antibody-drug conjugates (ADCs), and cytotoxic compounds. With occupational exposure limits commonly in the range of ng/m3, highly sensitive, fully validated analytical methods are required. We use HPLC, ELISA, EIA, and LC/MS/MS techniques, achieving high specificity, ultra-sensitivity, and high recovery rates through the proper choice of filter media and extraction procedures, as well as the optimization of air sampling parameters. The limit of quantitation (LOQ) for several of our assays is in the picogram per filter range, a powerful tool for air monitoring applications. View our AIHA-LAP accreditation certificate and scope of accreditation.
Submitting a Sample for Analysis
If you wish to submit a sample to our laboratory for analysis, please click the link below and follow the sample submission procedures.
To search our library of over 250 analytical methods, please visit our analytical method library.
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Industrial Hygiene Analytical Laboratory
AIHA-LAP Accreditation
Accreditation by the American Industrial Hygiene Association Laboratory Accreditation Programs (AIHA-LAP, LLC) for the analysis of active pharmaceutical ingredients means the following:
- Operating a quality system that meets the requirements of ISO/IEC 17025. This standard incorporates the principles of ISO 9001 that are relevant to the scope of testing services addressed by the laboratory.
- Operating a laboratory in which sampling and testing procedures are performed with adequate controls by well-qualified personnel using appropriate equipment, Standard Operating Procedures and validated methods
- Maintaining an ongoing Proficiency Testing (PT) program
- Participating in an independent third-party auditing program to ensure compliance with requirements
View the SafeBridge laboratory's AIHA-LAP accreditation certificate and scope of accreditation.
Methods for Biologically Active Pharmaceuticals
The SafeBridge analytical laboratory routinely develops methods to detect active pharmaceutical ingredients (APIs) collected as industrial hygiene air and surface samples using HPLC, ELISA, EIA, and LC/MS/MS techniques. This allows us to achieve high specificity and ultra-sensitivity, as well as high recovery rates through the proper choice of filter media, extraction procedures, and the optimization of air sampling parameters. The limit of quantitation (LOQ) for several of our assays is in the picogram per filter range, a powerful tool for detecting highly potent pharmaceuticals in the workplace.
Analysis of Pharmaceutical Samples
For the methods we develop, we are also capable of analyzing those APIs on air or surface samples collected as part of an industrial hygiene survey. Typical turnaround is three weeks, but that can be rushed for an expedited fee.
Analysis of Surrogate Materials
We also analyze surrogate samples collected during the verification of containment systems (containment performance assessment [CPA]). We typically use naproxen sodium, mannitol, and lactose as surrogates with a limit of quantitation as low as 5 picogram of material on a filter.
Cleaning Method Development
We conduct assessments of cleaning methodologies that are employed for both occupational and product contact surfaces and for QC/QA cleaning validation purposes. This will assist clients with selection of the proper solvents and cleaning processes to ensure that as much API is removed as possible.
Permeability Studies
Understanding the ability of potent pharmaceutical compounds to permeate through gloves and other protective equipment materials is essential for the proper selection of materials used in personal protective equipment (PPE). Our lab can perform studies to determine permeability through PPE.